Mixup-Inf-Net: A data augmentation algorithm for segmentation of new coronary pneumonia infections

In 2020, the global spread of Coronavirus Disease 2019 exposed entire world to a severe health crisis. This has limited fast and accurate screening of suspected cases due to equipment shortages and and harsh testing environments. The current diagnosis of suspected cases has benefited greatly from the use of radiographic brain imaging, also including X-ray and scintigraphy, as a crucial addition to screening tests for new coronary pneumonia disease. However, it is impractical to gather enormous volumes of data quickly, which makes it difficult for depth models to be trained. To solve these problems, we obtained a new dataset by data augmentation Mixup method for the used chest CT slices. It uses lung infection segmentation (Inf-Net [1]) in a deep network and adds a learning framework with semi-supervised to form a Mixup-Inf-Net semi-supervised learning framework model to identify COVID-19 infection area from chest CT slices. The system depends primarily on unlabeled data and merely a minimal amount of annotated data is required;therefore, the unlabeled data generated by Mixup provides good assistance. Our framework can be used to improve improve learning and performance. The SemiSeg dataset and the actual 3D CT images that we produced are used in a variety of tests, and the analysis shows that Mixup-Inf-Net semi-supervised outperforms most SOTA segmentation models learning framework model in this study, which also enhances segmentation performance. © 2023 SPIE.

Late gadolinium enhancement following covid-19 infection does not predict outcome: a single-centre study

182 Figure 1Cardiovascular events in COVID-19 Survivors by LGE Status[Figure omitted. See PDF] 182 Figure 2All-cause mortality in COVID-19 Survivors by LGE Status[Figure omitted. See PDF]Conflict of InterestNone

Semi-Supervised Modified-UNet for Lung Infection Image Segmentation

Automatic lung infection segmentation in computed tomography (CT) scans can offer great assistance in radiological diagnosis by improving accuracy and reducing time required for diagnosis. The biggest challenges for deep learning (DL) models in segmenting infection region are the high variances in infection characteristics, fuzzy boundaries between infected and normal tissues, and the troubles in getting large number of annotated data for training. To resolve such issues, we propose a Modified U-Net (Mod-UNet) model with minor architectural changes and significant modifications in the training process of vanilla 2D UNet. As part of these modifications, we updated the loss function, optimization function, and regularization methods, added a learning rate scheduler and applied advanced data augmentation techniques. Segmentation results on two Covid-19 Lung CT segmentation datasets show that the performance of Mod-UNet is considerably better than the baseline U-Net. Furthermore, to mitigate the issue of lack of annotated data, the Mod-UNet is used in a semi-supervised framework (Semi-Mod-UNet) which works on a random sampling approach to progressively enlarge the training dataset from a large pool of unannotated CT slices. Exhaustive experiments on the two Covid-19 CT segmentation datasets and on a real lung CT volume show that the Mod-UNet and Semi-Mod-UNet significantly outperform other state-of-theart approaches in automated lung infection segmentation. IEEE

Performance, Trust, or both? COVID-19 Diagnosis and Prognosis using Deep Ensemble Transfer Learning on X-ray Imagesg±

The COVID-19 pandemic still affects most parts of the world today. Despite a lot of research on diagnosis, prognosis, and treatment, a big challenge today is the limited number of expert radiologists who provide diagnosis and prognosis on X-Ray images. Thus, to make the diagnosis of COVID-19 accessible and quicker, several researchers have proposed deep-learning-based Artificial Intelligence (AI) models. While most of these proposed machine and deep learning models work in theory, they may not find acceptance among the medical community for clinical use due to weak statistical validation. For this article, radiologists' views were considered to understand the correlation between the theoretical findings and real-life observations. The article explores Convolutional Neural Network (CNN) classification models to build a four-class viz. "COVID-19", "Lung Opacity", "Pneumonia", and "Normal"classifiers, which also provide the uncertainty measure associated with each class. The authors also employ various pre-processing techniques to enhance the X-Ray images for specific features. To address the issues of over-fitting while training, as well as to address the class imbalance problem in our dataset, we use Monte Carlo dropout and Focal Loss respectively. Finally, we provide a comparative analysis of the following classification models - ResNet-18, VGG-19, ResNet-152, MobileNet-V2, Inception-V3, and EfficientNet-V2, where we match the state-of-the-art results on the Open Benchmark Chest X-ray datasets, with a sensitivity of 0.9954, specificity of 0.9886, the precision of 0.9880, F1-score of 0.9851, accuracy of 0.9816, and receiver operating characteristic (ROC) of the area under the curve (AUC) of 0.9781 (ROC-AUC score). © 2022 ACM.

Research on Chest X-Ray Image Diagnosis of Covid-19 Based on Improved ResNet

With the outbreak of covid-19 in 2020, timely and effective diagnosis and treatment of each covid-19 patient is particularly important. This paper combines the advantages of deep learning in image recognition, takes RESNET as the basic network framework, and carries out the experiment of improving the residual structure on this basis. It is tested on the open source new coronal chest radiograph data set, and the accuracy rate is 82.3%. Through a series of experiments, the training model has the advantages of good generalization, high accuracy and fast convergence. This paper proves the feasibility of the improved residual neural network in the diagnosis of covid-19. © 2023 SPIE.

HarDNet and Dual-Code Attention Mechanism based model for medical images segmentation

During the formation of medical images, they are easily disturbed by factors such as acquisition devices and tissue backgrounds, causing problems such as blurred image backgrounds and difficulty in differentiation. In this paper, we combine the HarDNet module and the multi-coding attention mechanism module to optimize the two stages of encoding and decoding to improve the model segmentation performance. In the encoding stage, the HarDNet module extracts medical image feature information to improve the segmentation network operation speed. In the decoding stage, the multi-coding attention module is used to extract both the position feature information and channel feature information of the image to improve the model segmentation effect. Finally, to improve the segmentation accuracy of small targets, the use of Cross Entropy and Dice combination function is proposed as the loss function of this algorithm. The algorithm has experimented on three different types of medical datasets, Kvasir-SEG, ISIC2018, and COVID-19CT. The values of JS were 0.7189, 0.7702, 0.9895, ACC were 0.8964, 0.9491, 0.9965, SENS were 0.7634, 0.8204, 0.9976, PRE were 0.9214, 0.9504, 0.9931. The experimental results showed that the model proposed in this paper achieved excellent segmentation results in all the above evaluation indexes, which can effectively assist doctors to diagnose related diseases quickly and improve the speed of diagnosis and patients’quality of life. Author

Prospects of TiO2-based photocatalytic degradation of microplastic leachates related disposable facemask, a major COVID-19 waste

COVID-19 is one of the serious catastrophes that have a substantial influence on human health and the environment. Diverse preventive actions were implemented globally to limit its spread and transmission. Personnel protective equipment (PPE) was an important part of these control approaches. But unfortunately, these types of PPE mainly comprise plastics, which sparked challenges in the management of plastic waste. Disposable face masks (DFM) are one of the efficient strategies used across the world to ward off disease transmission. DFMs can contribute to micro and nano plastic pollution as the plastic present in the mask may degrade when exposed to certain environmental conditions. Microplastics (MPs) can enter the food chain and devastate human health. Recognizing the possible environmental risks associated with the inappropriate disposal of masks, it is crucial to avert it from becoming the next plastic crisis. To address this environmental threat, titanium dioxide (TiO2)-based photocatalytic degradation (PCD) of MPs is one of the promising approaches. TiO2-based photocatalysts exhibit excellent plastic degradation potential due to their outstanding photocatalytic ability, cost efficiency, chemical, and thermal stability. In this review, we have discussed the reports on COVID-19 waste generation, the limitation of current waste management techniques, and the environmental impact of MPs leachates from DFMs. Mainly, the prominence of TiO2 in the PCD and the applications of TiO2-based photocatalysts in MPs degradation are the prime highlights of this review. Additionally, various synthesis methods to enhance the photocatalytic performance of TiO2 and the mechanism of PCD are also discussed. Furthermore, current challenges and the future research perspective on the improvement of this approach have been proposed.

Navigating the iodinated contrast media shortage: A review

The current COVID-19 climate has caused an unforeseen supply shortage of iodinated contrast media (ICM) worldwide, disrupting global distribution.1 In addition, the scarcity has resulted in a ripple effect in healthcare facilities such as radiology departments where ICM is required to perform contrast-enhanced examinations. ICM plays a significant part in contrast-enhanced CT, angiography and fluoroscopic procedures within the radiology department, holding a primary role in the differentiation and diagnosis of pathologies which range from pulmonary emboli to tumours.1 Its use extends beyond radiology, where ICM is heavily relied on in cardiology, urology and gastrointestinal studies, further highlighting the heavy dependence on the critical agent.2 With the global increase in the number of CT examinations requested, where approximately 60% of studies require ICM, optimal usage of ICM must be considered to meet heightened demand.3 The shortage has represented an opportunity for imaging providers to re-examine current imaging protocols and identify whether non-contrast imaging, alternative contrast agents and other imaging modalities could be viable options moving forward.1,2 Additionally, current literature has discussed volume-reduction strategies and dual-energy use in newer-generation CT scanners to conserve ICM.1,4 This review will explore currently proposed solutions that can be implemented in the radiology department to maximise ICM supply with minimal impact on patient care.

U-Net based Semantic Segmentation for Touchless Fingerprint Technology: A Reflective Review

Touch-based fingerprints are widely used in today's world;even with all the success, the touch-based nature of these is a threat, especially in this COVID-19 period. A solution to the same is the introduction of Touchless Fingerprint Technology. The workflow of a touchless system varies vastly from its touch-based counterpart in terms of acquisition, pre-processing, image enhancement, and fingerprint verification. One significant difference is the methods used to segment desired fingerprint regions. This literature focuses on pixel-level classification or semantic segmentation using U-Net, a key yet challenging task. A plethora of semantic segmentation methods have been applied in this field. In this literature, a spectrum of efforts in the field of semantic segmentation using U-Net is investigated along with the components that are integral while training and testing a model, like optimizers, loss functions, and metrics used for evaluation and enumeration of results obtained. © 2022 IEEE.

Role of Logistics Integration Capability in Enhancing Performance in Omni-Channel Retailing: Supply Chain Integration as Mediator

Although the importance and benefits of logistics integration in omni-channel (OC) retailing have been discussed in the literature, the impacts of logistics integration from the dimension of internal and external logistics remain unknown. To fill this gap, this study aims to investigate the relationships among internal and external logistics integration capabilities, supply-chain integration (SCI), and financial performance (FP) in OC retailing based on the dynamic capability view. An empirical study is conducted based on a survey of 230 OC retailers in China's market. Factor analysis and regression analysis are conducted to examine the hypotheses of the proposed conceptual model. The quantitative analyses show that the internal logistics integration capability is significantly related to the external logistics integration capability, and they both have positive effects on SCI, while the external logistics integration capability generates a higher impact (i.e., almost 1.5 times that of the internal logistics integration capability). The numerical results also demonstrate that the logistics integration capabilities and SCI have similar positive effects on FP (i.e., all the relevant regression coefficients show values around 0.25), and SCI plays a partial intermediary role in the relationships between logistics integration capabilities and FP. Furthermore, the quantitative evidence addresses the fact that the FP is not influenced by OC retailers' characteristics, indicating a fair business environment in the OC retail industry.

Multilevel Thresholding of Grayscale Complex Crop Images using Minimum Cross Entropy

Crop image segmentation plays a key step in the field of agriculture. The crop images present near the environs have complex backgrounds and their grayscale histogram is mostly multimodal. Hence, multilevel segmentation of grayscale crop images may be helpful for better analysis. This paper proposed multilevel thresholding of grayscale crop images incorporated with minimum cross entropy as an objective function. The time complexity of this technique increases with the threshold levels. Hence, the coronavirus herd immunity optimizer (CHIO) has been amalgamated with the objective function. This technique improves the image's accuracy. The CHIO is a humanbased algorithm that separates the foreground and background efficiently with multiple thresholds value. The simulation has been performed on grayscale crop images. It is. compared with bacterial foraging algorithm (BFO), and beta differential algorithm (BDE) to validate the accuracy. The results validates that the proposed method outperforms BFO and BDE for grayscale crop images in terms of fidelity parameters. The qualitative and quantitative results evidence the proficiency of suggested method. © 2023 IEEE.

Comparative Analysis of Laboratory and Radiation Methods of Studies with the Degree of Severity of Patients with COVID-19

The study is devoted to a comparative analysis and retrospective evaluation of laboratory and instrumental data with the severity of lung tissue damage in COVID-19 of patients with COVID-19. An improvement was made in the methodology for interpreting and analyzing dynamic changes associated with COVID-19 on CT images of the lungs. The technique includes the following steps: pre-processing, segmentation with color coding, calculation and evaluation of signs to highlight areas with probable pathology (including combined evaluation of signs). Analysis and interpretation is carried out on the emerging database of patients. At the same time the following indicators are distinguished: the results of the analysis of CT images of the lungs in dynamics;the results of the analysis of clinical and laboratory data (severity course of the disease, temperature, saturation, etc.). The results of laboratory studies are analyzed with an emphasis on the values of the main indicator - interleukin-6. This indicator is a marker of significant and serious changes characterizing the severity of the patient's condition. © 2023 IEEE.

Variables Affecting Congregation's Trust and Mosque Organizational Performance: Acces la Success

Mosque is a non-profit community organization, where the purpose of its establishment is not to seek profit, so this objective makes it different from commercial organizations. "Takmir" (manager of a mosque)as a manager, has the responsibility and trust of the congregation. This was explanatory research with a quantitative approach. The level of a good trust can be improved by consinously improving the quality of variabels so that the mosque organization managed can run properly and correctly and the congregation's trust can be achived. When the good mosque governance concept with the principles, internal control and services are used properly, it will be able to improve organization performance. Congregation's trust in the takmir to improve the performance of the mosque's organization can be achieved by increasing the ability, kindness and integrity of the takmir. The congregation's trust in the takmir will affect its intensity in participating in activities organized by the mosque, in which it will directly affect the performance of the mosque's organization. For Next research, it is recommended to add a variable of the concept of leadership from organizational managers. The participation variable from the congregation and the community, and professional variables, Professional someone will have a positive and significant impact on the quality of work.

Multi-Attentional U-Net for Medical Image Segmentation

Deep learning (DL) approaches for image segmentation have been gaining state-of-the-art performance in recent years. Particularly, in deep learning, U-Net model has been successfully used in the field of image segmentation. However, traditional U-Net methods extract features, aggregate remote information, and reconstruct images by stacking convolution, pooling, and up sampling blocks. The traditional approach is very inefficient due of the stacked local operators. In this paper, we propose the multi-attentional U-Net that is equipped with non-local blocks based self-attention, channel-attention, and spatial-attention for image segmentation. These blocks can be inserted into U-Net to flexibly aggregate information on the plane and spatial scales. We perform and evaluate the multi-attentional U-Net model on three benchmark data sets, which are COVID-19 segmentation, skin cancer segmentation, thyroid nodules segmentation. Results show that our proposed models achieve better performances with faster computation and fewer parameters. The multi-attention U-Net can improve the medical image segmentation results. © 2022 IEEE.

Immune enhancers for COVID-19

SARS-CoV-2, also known as COVID-19, is a novel coronavirus that began sweeping the globe at the end of 2019, causing mild illness in some patients while leading to devastating shock, immune dysregulation, multiorgan failure, and even death in others. Immune dysregulation may lead to increased susceptibility to severe disease from COVID-19. Immune enhancers could aid in immune regulation and protect against severe COVID-19 infection. Herbal supplements, spices, and lifestyle modifications have been shown to enhance immune responses to a number of pathogens, which may include COVID-19. These immune enhancers could be used adjunctively with vaccines, social distancing, and pharmacologic treatments to prevent life-threatening infection in susceptible patients. © 2023 Elsevier Inc. All rights reserved.

COVID-19 Detection on X-Ray Image Using Deep Learning

COVID-19 is one of the threats that came out of nowhere and literally shook the entire world. Various prediction techniques have been invented in a very short time. This study also develops a Deep Learning (DL) model which can predict the presence of COVID-19 and pneumonia by analyzing the X-ray images of human lungs. From Kaggle, a collection of X-ray images of the lungs is collected. Then, this dataset is preprocessed using two alternative methods. Some of the techniques include image enhancement and picture resizing. The two deep-learning models are then trained using the preprocessed dataset. A few more examples of DL algorithms include MobileNet and Inception-V3. The best model is then selected by validating the learned deep-learning models. As the epochs count increases during training and validation, the accuracy value for both models increases. The value of the loss increases as the number of epochs decreases. During the fourteenth validation period, the model generates a loss value of 0.32 for the MobileNet technique. During the first few training epochs, accuracy is lower, and by the fifteenth, it is close to 0.9. The Inception-V3 method produces a loss value of 0.1452 at the eleventh validation epoch, which is the lowest value. The greatest accuracy value of 0.9697 is obtained after the twelfth cycle of validation. The model that performs better and has lower loss values is then put through one last test. Inception-V3 is therefore selected as the top method for COVID-19 detection. The Inception-V3 system properly predicted each of the normal images and the COVID-19 images in the final test. Regarding pneumonia, it correctly predicted just one image out of 20 that are so small as to be disregarded. When a patient cannot afford to find a doctor for consultation, the DL model created in this work can be utilized as a preliminary test for COVID-19. By including the model created in this study as a backend processor for a website or software application, the study's findings can be updated. © 2023 IEEE.

A Deep Learning-Based Preventive Measures of COVID-19 in a crowd using Reinforcement Model over GAN for Enhanced efficiency

The fast human-to-human spread of COVID-19 has caused significant lifestyle changes for many individuals. At the end of January 2020, the pandemic began, and many nations responded with varying degrees of testing, sanitation, lockdown, and quarantine centers. New normals of testing, sanitization, social separation, and lockdown are being implemented, and people are gradually returning to work and other daily routines. The COVID-19 infected population is monitored by testing individuals regularly. But it's a resource-heavy endeavor to test everyone without good reason. An optimum strategy is required to efficiently identify persons who are most likely to test positive for COVID-19. Sanitation is utilized for both persons and public spaces to eliminate germs. However, the disruption of governmental operations and economic development makes the use of lockdown and quarantine centers a resource-intensive endeavor. Conversely, it degrades the standard of living across a society. Furthermore, keeping people inside their houses or quarantine centers for an unlimited amount of time would not allow the government to care for everyone. These variables impact virus propagation, human health and happiness, available resources, and the economy's health, making their management resource-intensive. counting and density estimation are both attempts to create clever and efficient algorithms that can interpret the data provided by images to carry out Efficiency. GANs have been proven to have promising applications in overcoming the data dearth problem in COVID-19 lung image analysis. The Convolutional Neural Network (CNN) models built for the diagnosis of COVID-19 have benefited from the GAN-generated data used to refine their training. Moreover, GANs have helped improve the performance of CNNs by super-resolving pictures and performing segmentation. This work highlights the Reinforcement deep learning model over the fundamental constraints of the possible transformation of GANs-based approaches. This work proposes the model be developed with a new intelligent approach using RL to quantify these different types of testing considered for social distancing, face mask detection, limiting the gathering, and locking the location using the Q Learning technique. Different RL algorithms are implemented, and agents are equipped with these algorithms so that they may interact with the environment and learn the optimum method for doing so. © 2023 IEEE.

Deep Learning for Detection and Prediction of Covid-19 Virus on CT-Scan Image Dataset

As we all know, COVID-19 appears to be having a terrible impact on world health and well-being. Furthermore, at its peak, the COVID-19 cases worldwide reached a huge number i.e., in millions. The objective of the present work is to develop a model that detects COVID-19 utilizing CT-Scan Image Dataset and DL Techniques. As the number of verified cases rises, it becomes more critical to monitor and precisely categorize healthy and infected people. RT-PCR testing is the most used approach for the detection of Covid-19. However, several investigations have found that it has a low sensitivity in the early stages. Computer tomography (CT) is also used to detect image-morphological patterns of COVID-19-related chest lesions. The RT-PCR technique for diagnosing COVID has some drawbacks. For starters, test kits are insufficiently available, necessitating greater testing time and the sensitivity of testing varies. Therefore, employing CT scan pictures to screen COVID-19 is essential. The results showed that CT scan pictures might efficiently identify COVID-19, saving more lives. A Convolutional Neural Network (CNN) is a sort of Artificial Neural Network that is commonly used for image/object detection with class. An Input layer, Hidden layers, and an Output layer are common components of a neural network (NN). CNN is inspired by the brain's architecture. Artificial neurons or nodes in CNNs, like neurons in the brain, take inputs, process them, and deliver the result as output. Illness severity can be detected and calculated for future scopes and research. Another challenge encountered when dealing with severity infection detection and extending the existing work by using frameworks in order to increase accuracy. The proposed ECNN technique outperformed than CNN in terms of accuracy (95.35), execution time, and performance. This study could be extended or improved in the future by directing severity identification on the CT-Scan image dataset. © 2023 IEEE.

A Dual-Approach Strategy to Optimize the Safety and Efficacy of Anti-Zika Virus Monoclonal Antibody Therapeutics.

Antibody-dependent enhancement of infection (ADE) is clinically relevant to Dengue virus (DENV) infection and poses a major risk to the application of monoclonal antibody (mAb)-based therapeutics against related flaviviruses such as the Zika virus (ZIKV). Here, we tested a two-tier approach for selecting non-cross-reactive mAbs combined with modulating Fc glycosylation as a strategy to doubly secure the elimination of ADE while preserving Fc effector functions. To this end, we selected a ZIKV-specific mAb (ZV54) and generated three ZV54 variants using Chinese hamster ovary cells and wild-type (WT) and glycoengineered ΔXF Nicotiana benthamiana plants as production hosts (ZV54CHO, ZV54WT, and ZV54ΔXF). The three ZV54 variants shared an identical polypeptide backbone, but each exhibited a distinct Fc N-glycosylation profile. All three ZV54 variants showed similar neutralization potency against ZIKV but no ADE activity for DENV infection, validating the importance of selecting the virus/serotype-specific mAbs for avoiding ADE by related flaviviruses. For ZIKV infection, however, ZV54CHO and ZV54ΔXF showed significant ADE activity while ZV54WT completely forwent ADE, suggesting that Fc glycan modulation may yield mAb glycoforms that abrogate ADE even for homologous viruses. In contrast to the current strategies for Fc mutations that abrogate all effector functions along with ADE, our approach allowed the preservation of effector functions as all ZV54 glycovariants retained antibody-dependent cellular cytotoxicity (ADCC) against the ZIKV-infected cells. Furthermore, the ADE-free ZV54WT demonstrated in vivo efficacy in a ZIKV-infection mouse model. Collectively, our study provides further support for the hypothesis that antibody-viral surface antigen and Fc-mediated host cell interactions are both prerequisites for ADE, and that a dual-approach strategy, as shown herein, contributes to the development of highly safe and efficacious anti-ZIKV mAb therapeutics. Our findings may be impactful to other ADE-prone viruses, including SARS-CoV-2.

Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity.

Immunoglobulin G (IgG) antibodies are widely used for diagnosis and therapy. Given the unique dimeric structure of IgG, we hypothesized that, by genetically fusing a homodimeric protein (catenator) to the C-terminus of IgG, reversible catenation of antibody molecules could be induced on a surface where target antigen molecules are abundant, and that it could be an effective way to greatly enhance the antigen-binding avidity. A thermodynamic simulation showed that quite low homodimerization affinity of a catenator, e.g. dissociation constant of 100 µM, can enhance nanomolar antigen-binding avidity to a picomolar level, and that the fold enhancement sharply depends on the density of the antigen. In a proof-of-concept experiment where antigen molecules are immobilized on a biosensor tip, the C-terminal fusion of a pair of weakly homodimerizing proteins to three different antibodies enhanced the antigen-binding avidity by at least 110 or 304 folds from the intrinsic binding avidity. Compared with the mother antibody, Obinutuzumab(Y101L) which targets CD20, the same antibody with fused catenators exhibited significantly enhanced binding to SU-DHL5 cells. Together, the homodimerization-induced antibody catenation would be a new powerful approach to improve antibody applications, including the detection of scarce biomarkers and targeted anticancer therapies.